Pre-eclampsia is the most common complication in obstetric in pregnant women,but the real pathogenesis is still poorly understood.Family-based studies have confirmed that the incidence of pre-eclampsia is related to genetic factors.In this study,we evaluated the associations between the adipose most abundant gene transcript-1(APM1)gene SNPs and pre-eclampsia in Chinese Han women of pregnancy.A total number of 492 Han Chinese pregnant women were enrolled in this case-control study(221 cases and 271 normal pregnant subjects).We detected+45T>G,+712A>G and+4545C>G single nucleotide polymorphic loci genotypes of APM1 with the method of polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).The genotypic distribution of controls was tested by HWE software,and all the three SNPs p-values were greater than 0.05.Our study showed that pre-eclampsia was accompanied by dyslipidemia and +45T allele homozygous had a relatively lower TC level than G carrier genotype(TG+GG)in the case group.Logistic regression analysis of risk factors on pre-eclampsia showed that+4545C>G was one of the genetic factors.There is a strong linkage disequilibrium between polymorphic locis+45T>G and+712A>G;+45T>G and+4545T>G,+712A>G and+4545T>G.APM1 gene SNPs+45T>G and+712A>G are contributed to lipid metabolism disorders and+4545C>G has an significantly impact on the incidence of pre-eclampsia in Chinese.But we havent found an obvious evidence to confirm an association between APM1 studied alleles,genotypes or haplotypes frequencies and pre-eclampsia.