亚洲玉米螟几丁质酶OfChtⅠ抑制剂的设计

来源 :中国化学会第十届全国化学生物学学术会议 | 被引量 : 0次 | 上传用户：capfhn

【摘要】

：

几丁质酶在昆虫生长发育过程中起着十分重要的作用，其中，分支Ⅰ(groupⅠ)几丁质酶主要负责昆虫蜕皮过程中旧表皮的降解，被认为是农药设计的潜在靶标。亚洲玉米螟几丁质酶OfChtⅠ 属于groupⅠ 几丁质酶，通过分析其催化域的晶体结构，发现在其活性腔中存在一系列疏水性氨基酸，在底物与酶结合中起着重要作用[1]。

【作者】

：

董雅雯胡松张莉

【机构】

：

中国农业大学理学院应用化学系北京市海淀区圆明园西路2号,100093

【出处】

：

中国化学会第十届全国化学生物学学术会议

【发表日期】

：

2017年10期

【关键词】

：

亚洲玉米螟几丁质酶抑制剂虚拟筛选

下载到本地 , 更方便阅读

下载此文赞助VIP

声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架

论文部分内容阅读

其他文献

Design,Synthesis,and Fungicidal Activity of Substituted Cinnamaldehyde Thiosemicarbazone Inhibitors

Melanin has the significant physiological function not only in the growth of insect but also in fungi and bacteria.

会议

ThiosemicarbazideTyrosinase inhibitorPiperidine derivativesFungicidal activit

Glycosylation of CD147 promote cancer cell invasion:regulation study with novel inhibitors and DNA-e

Tumor migration is one of the most important reasons for failure treatment of patients in late-stage [1].

会议

CD147inhibitorfluorescent sensorcancer invasion

Identification of the hot spot residues for ATP substrate and the pyridine derivative inhibitor CCT2

Protein kinase monopolar spindle 1 plays an important role in spindle assembly checkpoint at the onset of mitosis [1].

会议

MPS1inhibitormolecular dynamic simulationhotspotMM/PBSA

Development of 4-amidobenzimidazole acridine derivatives as dual PARP and Topo inhibitors for cancer

PARP-1 is closely related to the repair of DNA damages caused by Topo inhibitors.The combinations of PARP-1 inhibitor and Topo inhibitor display enhanced antitumor potency and might help to overcome r

会议

AcridineAmidobenzimidezolePARPTopoAntitumor bioactivity

Inhibitor Screening based on Cyanobacteria FBP/SBPase

Cyanobacteria produce harmful algal blooms(HABs)and then cause water pollution worldwide and a hazard to animal and human health.Cyanobacterial fructose-1,6-/sedoheptulose-1,7-bisphosphatase(Cy-FBP/SB

会议

cyanobacteria FBP/SBPaseinteractionlead compoundalgicide

抗癌细胞多药耐药的取代喹啉酰胺及其衍生物的合成与活性

ABC 细胞膜转运蛋白是一个能转运多种底物的蛋白质家族，目前研究认为其中的许多成员在宿主对异物的防御机制和肿瘤细胞对抗癌药物的耐药性中起重要作用[1]。由于ABC 细胞膜转运蛋白能将已进人细胞的外源性物质从胞内泵出胞外，所以是肿瘤细胞多药耐药的主要原因，其基因表达水平与细胞内药物浓度和耐药程度密切相关。

会议

多药耐药P-gp抑制剂喹啉酰胺衍生物

Transcriptome-wide discovery of coding and noncoding RNA-binding proteins by click chemistry-assiste

Identification of RNA-binding proteins(RBPs)is a prerequisite for understanding the posttranscriptional gene regulation networks.However,current large-scale RBP identification strategies are mostly ba

会议

RNA-binding proteinsmetabolic labelingclick chemistryproteomics

Selective imaging of Gram-negative and Gram-positive microbiotas

The diverse gut microbial communities are crucial for host health.How the interactions between microbial communities and between host and microbes influence host,however,has not been well understood.

会议

Microbiota imagingselective labelingvancomycinKdopolymyxin B

Novel 6-methoxycarbonyl indolinones bearing a pyrrole moiety as angiokinase inhibitors

Angiogenesis is critical to the growth of solid tumors,and is regulated by a complex balance between a number of endogenous molecules,such as VEGFRs,PDGFRs,and FGFRs.

会议

6-methoxycarbonyl indolinoneangiokinase inhibitorantiproliferative activity

QSAR和MM-PBSA在EcR蜕皮激动剂虚拟筛选中的应用

蜕皮激素受体(ecdysone receptor,EcR)广泛存在于昆虫体内,是绿色农药设计的重要靶标1.双酰肼类化合物作用机制与天然蜕皮激素类似,通过与EcR 结合,启动与昆虫蜕皮相关的转录因子,但因其不易被清除,导致昆虫持续蜕皮,最终因饥饿、失水死亡.

会议

蜕皮激素受体蜕皮激动剂虚拟筛选QSARMM-PBSA

亚洲玉米螟几丁质酶OfChtⅠ抑制剂的设计

与本文相关的学术论文