Discovery of 1-Aryloxyethyl Piperazine Derivatives as Kv1.5 Potassium Channel Inhibitors

来源 :2015年全国药物化学学术会议暨第五届中英药物化学学术会议 | 被引量 : 0次 | 上传用户：Hawk8

【摘要】

：

Kv1.5 potassium channel is an efficacious and safe therapeutic target for the treatment of atrial fibrillation(AF),the most common arrhythmia that threatens human.Herein,by modifying the hit compound

【作者】

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Xiaoke Guo Haopeng Sun Qidong You

【机构】

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Jiang Su Key Laboratory of Drug Design and Optimization,China Pharmaceutical University,Nanjing 2100

【出处】

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2015年全国药物化学学术会议暨第五届中英药物化学学术会议

【发表日期】

：

2015年3期

【关键词】

：

Atrial fibrillation Kv1.5 potassium channel structure-activity relationship

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　　Kv1.5 potassium channel is an efficacious and safe therapeutic target for the treatment of atrial fibrillation(AF),the most common arrhythmia that threatens human.Herein,by modifying the hit compound 7k from an in-house database,48 derivatives were synthesized for the assay of their Kv1.5 inhibitory effects by whole cell patch clamp technique.

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Discovery of 1-Aryloxyethyl Piperazine Derivatives as Kv1.5 Potassium Channel Inhibitors

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