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Aim: Esophageal squamous cell carcinoma (ESCC) is one of the most common malignant tumors.The oncogene c-MYC is thought to be important in the initiation, promotion, and therapy resistance of cancer.In the present study, the aim of this study was to investigate the clinicopathologic roles of c-MYC in ESCC tissue.Methods: Present study is aimed at discovering and analyzing c-MYC expression in a series of human esophageal tissues.95 ESCC samples were analyzed by the WB and IHC techniques.Then, correlation of c-MYC expression with clinicopathological features of ESCC patients was statistically analyzed.Results: Compared with normal and atypical hyperplasia tissues, c-MYC was higher expressed in esophageal cancer tissue.In most ESCC cases, the c-MYC expression was positive in tumor tissues, The PR (positive rate) of c-MYC expression in tumor tissues was 66.32% (63/95), obviously higher than the adjacent normal tissues (ANT) (4.21%, 4/92) and Atypical hyperplasia tissues (25.26%, 24/95).There was a statistical difference among ANT, Atypical hyperplasia tissues and tumor tissues.Over-expression of the c-MYC was detected in 66.32% (63 of 95) ESCCs, which was significantly correlated with the degree of differentiation (P =0.000).The PR of c-MYC expression was 40.0% (6/15) in well differentiated esophageal tissues, and 41.4% (24/58) in moderate differentiated esophageal tissues, but only 90.9% (20/22) in poor differentiated tissues, with a significantly statistical difference (P =0.000).The PR of c-MYC was 41.5% (17/41) in T1+T2 esophageal tissues, and 87.0% (47/54) in T3+T4 esophageal tissues, with a significantly statistical difference (P =0.000).The PR of c-MYC was 30.0% (12/40) in Ⅰ +Ⅱ esophageal tissues, and 89.1% (49/55) in Ⅲ+Ⅳ esophageal tissues, with a significantly statistical difference (P =0.000).The PR of c-MYC was 86.8% (46/53) in T1+T2 esophageal tissues, and 40.5% (17/42) in T3+T4 esophageal tissues, with a significantly statistical difference either (P =0.000).The C-MYC expression strongly correlated with clinical staging (P=0.000), differentiation degree (P=0.000), lymph node metastasis (P=0.000) and invasion depth (P=0.000) of patients with ESCC.Conclusion: The c-MYC was differentially expressed in a series of human esophageal tissues, and the aberrant c-MYC expression could be a potential factor in carcinogenesis and progression of ESCC.There was a statistical signification for c-MYC in ESCC patients to analyze clinicopathological features.It possibly become a new diagnostic indicators of ESCC.