【摘 要】
：
B cell-activating factor(BAFF)plays a fundamental role in B lymphocyte survival and homeostasis,and aberrant BAFF signalling is closely related to numerous autoimmune disorders.
【机 构】
：
State Key Laboratory of Natural and Biomimetic Drugs,School of Pharmaceutical Sciences,Peking Univer
论文部分内容阅读
B cell-activating factor(BAFF)plays a fundamental role in B lymphocyte survival and homeostasis,and aberrant BAFF signalling is closely related to numerous autoimmune disorders.
其他文献
Hydrogen molecule,a special antioxidant,has been seem as a promising potential therapeutic medicine to treat many inflammation-related diseases,including neurodegenerative diseases.
肿瘤乏氧是癌症治疗的主要障碍之一。设计在能乏氧环境下被激活的诊疗药物是一项很大的挑战。在这项研究中，我们设计了一系列具有蒽醌结构的环金属Ir(Ⅲ)配合物，用于乏氧癌症诊疗。该系列配合物在生理条件下能够稳定存在，在乏氧下激活，显示黄色荧光并能有效的探测3D 细胞球内部。
Copper enrichment in the brain is highly related to Alzheimers disease(AD)pathogenesis,but in vivo tracing of Cu2+in the brain by imaging techniques is still a great challenge.
Interferon gamma(IFN-γ)is an important N-glycosylated protein produced primarily by T-lymphocytes and natural killer cells.[1] As a cytokine that is crucial for innate and adaptive immunity against vi
Enzymes of CXXC family bind DNA at CGIs to play essential roles in epigenetic regulation.However,the dynamic mechanism of how a CGI containing multiple CpG clusters recruits enzymes with conserved CXX
内质网在细胞中有多重作用，其既是蛋白质折叠构成高级结构的场所，同时也是细胞内钙离子的贮存池以及脂质与胆固醇的合成场所。细胞内多种稳态被扰乱的时候都会对内质网产生影响，导致一种被称为内质网应激的现象。当内质网应激发生时，内质网中的钙离子极易溢出，与多种通路联通并诱发活性氧物种(ROS)过量产生，同时可以激活凋亡或坏死通路导致细胞死亡。
阿尔茨海默病(Alzheimers disease,AD)又称老年痴呆症,是一种与年龄相关的神经退行性疾病,表现为记忆力衰退、认知能力下降等。其典型的病理特征为淀粉样蛋白Aβ在胞外聚集形成老年斑(senile plaque,SP),Tau 蛋白过度磷酸化在胞内形成神经纤维缠结(neurofibrillary tangles,NFT),以及神经元的大量丢失和死亡。
Theranostic nanoagents are in great demand to meet the request of precision medicine.Herein,taken the advantage of Ir(Ⅲ)complex and gold nanorod,bifunctional theranostic nano-agent,Ir@AuNRs,was develo
DNA 的超长度和双螺旋性质使其在在复制、转录和基因表达的过程中需要不断地进行超螺旋和解旋状态之间的转换,在这一过程中,DNA 拓扑异构酶(topoisomerase,Topo)可催化改变 DNA 的拓扑结构,解决构象转换问题。研究表明,Topo 在肿瘤细胞中表现出高表达,因此,可以通过影响Topo 酶的作用过程来抑制酶的活性,进而达到抗肿瘤的效果。
Pancreatic cancer is one of the deadliest cancer with high metastasis rate and a dismal prognosis.Integrins,a class of transmembrane protein,are generally overexpressed in pancreatic tumors and play f