【摘 要】
：
Objective: To prepare fenofibrate nanoliposome (FNB-Nanolipo) and investigate its characterizations, oral pharmacokinetic profiles as well as its inhibition effects on nonalcoholic fatty liver disease
【机 构】
：
Institute of Cardiovascular Sciences, Peking University Health Science Center, Peking University Bei
【出 处】
：
2015年中国药物制剂大会、中国药学会药剂专业委员会2015年学术年会暨国际控释协会中国分会2015年学术年会
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Objective: To prepare fenofibrate nanoliposome (FNB-Nanolipo) and investigate its characterizations, oral pharmacokinetic profiles as well as its inhibition effects on nonalcoholic fatty liver disease (NAFLD) in mice.Methods: FNB-Nanolipo was prepared using a dry-film dispersing method.Its characterizations (particle size, encapsulation efficacy, in vitro release profiles, etc.) were evaluated.Also,its pharmacokinetic (PK) profiles after a single dose by gavage in mice, including area under curve (AUC)and main PK parameters were studied and compared with those of fenofibrate crude drug (FNB).
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