The development of promising photodynamic therapy(PDT) agents that bind to DNA for cancer treatment have drawn much more attentions recently.[1-2] In this work,IrⅢ-containing luminescent metallohelices by using a preformed facial Ir(ppy)3 handle which decorated with three aldehyde groups,then condensed with linear diamine spacers through dynamic covalent chemistry were designed and synthesized for the first time.