【摘 要】
：
Drug resistance in HIV-1 protease can also occasionally confer a change in the substrate specificity.Through the use of computational techniques,a relationship can be determined between the substrate
【机 构】
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Bogazici Univerisity, Chemical Engineering Department and Polymer Research Center,34342 Bebek, Istan
【出 处】
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2006中国天津世界艾滋病日科技会议
论文部分内容阅读
Drug resistance in HIV-1 protease can also occasionally confer a change in the substrate specificity.Through the use of computational techniques,a relationship can be determined between the substrate sequence and three-dimensional structure of HIV-1 protease,and be utilized to predict substrate specificity.In this study,we introduce a biased sequence search threading (BSST) methodology to analyze the preferences of substrate positions and correlations between them that might also identify which positions within known substrates can likely tolerate sequence variability and which cannot.The potential sequence space was efficiently explored using a low-resolution knowledge-based scoring function.
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