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AIM:Pulmonary arterial hypertension (PAH) is a disease characterized by thickening of pulmonary artery walls,elevated pulmonary vascular resistance,pulmonary vascular thrombotic lesions and right-heart failure.15-lipoxygenase (15-LO) /15-hydroxyeicosatetraenoic acid (15-HETE) was an important mediator in the regulation of hypoxic pulmonary hypertension,including the pulmonary vasoconstriction and remodeling.