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Time Domain Neal-Smith (TDNS) criterion is an ideal method for evaluation PIO susceptibility.The characteristic of pilot's self-adapting make it difficult to apply the criterion.In this paper.Sequential quadratic programming (SQP) algorithm is used for TDNS criterion, and the PIO susceptibility of an example aircraft is evaluated.The evaluation results indicate that it is practicable to evaluate PIO susceptibility by TDNS criterion with SQP algorithm.