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Renal cell carcinoma (RCC) is the most common malignancy in adult kidney,and accounts for 3% of malignancies worldwide with increasing incidence.Clear cell RCC (ccRCC) is the major type in RCC.Resection by surgery is the main treatment because ccRCC is highly resistant to traditional therapies,such as radiation and chemotherapy.We have identified 201 up-regulated genes and 182 down-regulated genes in ccRCC by comparison of full-length enriched cDNA libraries of ccRCC and normal kidney constructed by the oligo-capping method.