Region-specific brain organoids as a platform for CNS disease modeling

来源 :第九届广州国际干细胞与再生医学论坛暨第五届中国再生细胞生物学年会 | 被引量 : 0次 | 上传用户：huojugjf

【摘要】

：

Recent studies described the generation of three-dimensional organoids which share the key structural and cellular features of various organs by inducing the self-organization of pluripotent stem cell

【作者】

：

Tae Hwan Kwak Sai hali Seon In Hwang Kyu Ree Kang Dong Wook Han

【机构】

：

Department of Stem Cell Biology,School of Medicine,Konkuk University,1 Hwayang-dong,Gwangjin-gu,Seou

【出处】

：

第九届广州国际干细胞与再生医学论坛暨第五届中国再生细胞生物学年会

【发表日期】

：

2016年5期

【关键词】

：

Brain Organoid Cerebral cortex Mid Brain

下载到本地 , 更方便阅读

下载此文赞助VIP

声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架

论文部分内容阅读

其他文献

Interactome of Jmjd1a and Jmjd2c regulate pluripotency in embryonic stem cells

Jmjd1a and Jmjd2c are well-known epigenetic regulators that play significant role in stem cell identity through demethylating H3K9Me2 and H3K9Me3,respectively.

会议

Jmjd1aJmjd2cpluripotencyembryonic stem cellenhancer

Harmine,a natural product capable of in situ reprogramming

Harmine is a natural compound possessing insulin-sensitizing effect in db/db diabetic mice.However its effect on adipose tissue browning(reprogramming)is unknown.

会议

Obesitybrownings

Nanog Regulates the Pluripotency of ESCs through Distinct Pathways

To better understand how Nanog functions in regulating self-renewal and maintaining pluripotency,we report in this study our improved in vivo biotinylation approach for affinity purification of Nanog-

会议

NanogInteractomePluripotency

Gadd45a is a heterochromatin relaxer that enhances iPS cell generation

Reprogramming of somatic cells to induced pluripotent stem cells rewrites the code of cell fate at the chromatin level.Yet,little is known about this process physically.

会议

chromatin relaxerFRAPGadd45aheterochromatinrelaxationreprogramming

Pyrimidoindole derivative UM171 enhances derivation of hematopoietic progenitor cells from human plu

In the field of hematopoietic regeneration,deriving induced hematopoietic stem cells(iHSCs)from pluripotent stem cells with engraftment potential is the central mission.

会议

UM171hematopoietic stem and progenitor cellshematopoietic derivation

Effect of hydrogen sulfide on the mixed and purified cardiac cells in 2D and 3D models

The healing property of reperfusion therapy that one of the treatments for myocardial infarction(MI)is limited by the damage which called ischemia-reperfusion injury(IRI)soon flowed.

会议

Ischemia reperfusionHydrogen sulfideCardiac stem cellNanofiber

Establishment of a congenital amegakaryocytic thrombocytopenia model and a thrombocyte-specific repo

Mutations in the human myeloproliferative leukemia protein gene(MPL)are known to cause congenital amegakaryocytic thrombocytopenia(CAMT).The prognosis of this heritable disorder is poor and bone marro

会议

thrombocytethrombocytopeniamplzebrafish

RNA Helicase DDX5 Inhibits Reprogramming to Pluripotency by Repression of RYBP and its Dual Function

RNA-binding proteins(RBPs)are involved in a wide variety of functions in mammalian cells,including lineage specification and maintaining cellular identity.

会议

RNA binding proteinDDX5RYBPSomatic Cell Reprogramming

Suppressing P16Ink4a and P14ARF Pathways Overcomes Apopotosis in Individualized Human Embryonic Stem

Dissociation-induced apoptosis is a striking phenomenon in human embryonic stem cells(hESCs),but not in na(i)ve mouse ESCs.ROCK-dependent actinmyosin hyperactivation is an underlying mechanism to trig

会议

BMI1hESCsmESCs

STUDY OF NEURAL STEM CELLS MICROENVIRONMENT CONSTRUCTION IN A MOUSE BRAIN:BY ANALYSIS OF EXTRACELLUL

Neural stem cell(NSC)s are special cells which have capacity of self-renewal and the potencies to differentiate with multi-direction,such as neurons,astrocytes and oligodendrocytes both in vitro and v

会议

neural stem cellextracellular matrix

Region-specific brain organoids as a platform for CNS disease modeling

与本文相关的学术论文