肺癌远期疗效至今不满意,其主要原因是早期诊断困难,尤其在X线检查为阴性的所谓“隐性肺癌”。Saccomanno等(1965)曾报告一例隐性肺癌的隐匿期长达7年之久。Black等研究肺癌死亡病例中,尸检发现12%的病例对侧患有原位癌。随着痰细胞学检查的普及和纤维支气管镜的广泛应用,对隐性肺癌的报导日渐增多而且远期疗效亦随之提高。Frank(1976)报告一组61例隐性肺癌,确诊为原位癌并行手术治疗,术后2～22年随访仅2例死于肺癌。Woolner(1970)报导28例原位癌和早期浸润癌手术切除,术后3～17年随访无一例死于肺癌。 The long-term curative effect of lung cancer has been unsatisfactory so far. The main reason is that early diagnosis is difficult, especially in the so-called “hidden lung cancer” where the X-ray examination is negative. Saccomanno et al. (1965) reported one case of latent lung cancer for a period of up to 7 years. Black et al. studied lung cancer deaths. Autopsy found that 12% of patients had carcinoma in situ on the contralateral side. With the popularization of sputum cytology and the wide application of fiberoptic bronchoscopy, there has been an increase in reports of covert lung cancer and long-term efficacy. Frank (1976) reported a group of 61 cases of latent lung cancer, diagnosed as concurrent surgery for carcinoma in situ, and only 2 cases died of lung cancer after 2 to 22 years of follow-up. Woolner (1970) reported 28 cases of carcinoma in situ and early invasive carcinoma. None of the patients were followed by lung cancer after 3 to 17 years of follow-up.