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  5. Abamectin resistance in Drosophila is related to increased expression of P-glycoprotein via the dEGF

Abamectin resistance in Drosophila is related to increased expression of P-glycoprotein via the dEGF

来源 :The 10th Conference of Insect Physiology, Biochemistry and M | 被引量 : 0次 | 上传用户：A88851258
【摘 要】
：
Many insects have evolved resistance to abamectin but the mechanisms involved in this resistance have not been well characterized.P-glycoprotein (P-gp), an ATP-dependent drug-efflux pump transmembrane
【作 者】
：
Liang Luo Yin-Jian Sun Yi-Jun Wu 
【机 构】
：
Laboratory of Molecular Toxicology, State Key Laboratory of Integrated Management of Pest Insects an
【出 处】
：
The 10th Conference of Insect Physiology, Biochemistry and M
【发表日期】
：
2013年4期
【关键词】
：
avermectin resistance Drosophila EGFR Akt 
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Many insects have evolved resistance to abamectin but the mechanisms involved in this resistance have not been well characterized.P-glycoprotein (P-gp), an ATP-dependent drug-efflux pump transmembrane protein, may be involved in abamectin resistance.We investigated the role of P-gp in abamectin (ABM) resistance in Drosophila using an ABM-resistant strain developed in the laboratory.
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