Objective.This meta-analysis was used to evaluate the skeletal-related events(SREs)and efficacy of denosumab versus zoledronic acid(ZA)in patients with bone metastases.Methods.The data of this meta-analysis study were searched from PUBMED,EMBASE,Cochrane Library,Web of Science with Conference Proceedings,Elsevier and China National Knowledge Infrastructure(CNKI)databases till August 2015.Two independent reviewers reviewed the reference lists of relevant articles.The fixed-effects model and random-effects model were used to summarize relative estimates and 95%confidence intervals(CIs)according to the heterogeneity of the included studies.