【摘 要】
:
Objective: To observe the variation of serum vascular endothelial growth factor (VEGF), short-term efficacy and tolerability in esophageal cancer (EC) patients treated by radiotherapy plus thalidomide
【机 构】
:
213003 南京医科大学附属常州市第二人民医院放疗科
【出 处】
:
第十七届全国临床肿瘤学大会暨2014年CSCO学术年会
论文部分内容阅读
Objective: To observe the variation of serum vascular endothelial growth factor (VEGF), short-term efficacy and tolerability in esophageal cancer (EC) patients treated by radiotherapy plus thalidomide.Method: The serum samples of 86 EC patients were collected before, during and after radiotherapy, and the VEGF level was examined by ELISA.According to the change of serum VEGF level during radiotherapy,the patients were divided into two groups: in the drug group VEGF level was increased or remained unchanged, and thalidomide was administered till the end of radiotherapy;in the non-drug group VEGF level was decreased and radiotherapy was given alone to the end.Thirty healthy volunteer served as controls.
其他文献
目的:通过裸鼠体内实验探讨亨廷顿相关蛋白1(Huntingtin-Associated Protein 1,HAP1)过表达对人乳腺癌细胞MCF-7增殖生长的抑制作用及其可能机制,以期为乳腺癌提供新的基因治疗靶点.方法:1)构建裸鼠荷瘤模型:15只体重均等的4周龄雌性裸鼠被随机分成3组,每组5只,普通细胞株MCF-7和前期已构建完成的空质粒pBabe-puro(嘌呤霉素)转染细胞株以及pBabe-
目的:随着医学科技的发展,许多新型的药物,特别是包括赫赛汀在内的靶向治疗药物的出现,给乳腺癌患者带来新的曙光.但在临床工作中我们发现最终仍有相当一部分患者死于肿瘤耐药带来的复发或转移.其中,包括肿瘤耐药蛋白的表达、旁路基因的激活、DNA多态性等多种参与乳腺癌治疗耐药的具体机制已经引起学者的关注.
目的:microRNA是一个短小的,在转录后水平高度保守的,由18-25个核苷酸调控基因表达的非编码小分子RNA分子,通过靶mRNA的3非翻译的区(3UTR)内结合到互补的结合位点,miRNA的破坏它的翻译过程或促进其降解或翻译抑制,翻译后调控的miRNA被认为是基因表达的一个微调机构.
目的: To report a case of bilateral breast cancer following augmentation mammaplasty with polyacrylamide hydrogel injection and draw lessons of diagnosis and therapies.方法: Clinical Case Report.结果: Some
Objective: Locally advanced rectal cancer patients with ypT0-2N0 have good prognosis and may not need the cycle number of adjuvant chemotherapy as much as patients with poor (ypT3-4 or N+) response.Th
Objective: The neutrophil-lymphocyte ratio (NLR) has been proposed as an indicator of systemic inflammatory response and may predict the clinical outcome in some cancers, such as head and neck cancer
Objective: The objectives of our study were to assess the incidence of Chemotherapy-Induced Amenorrhea (CIA)and to determine predictive factors for CIA in pre-or perimenopausal women treated with adju
Objective: Epidermal growth factor receptor tyrosine kinase (EGFR-TK) inhibitors are useful in treating different advanced human cancers;however, their clinical efficacy varies.This study detected K-r
目的:探讨超声引导下经皮微波消融(MWA)治疗可手术切除的结直肠癌肝转移瘤的治疗价值.方法:回顾性分析我院2011年01月至2014年3月住院的18例结直肠癌肝转移瘤行微波消融治疗的患者,所有患者均为结直肠癌手术后出现肝转移,经肝穿刺活检术证实转移灶来自于结直肠癌.肝转移瘤均可行手术切除,但因患者高龄、体质状况较差或KPS评分差不适合及不愿行手术切除.
目的:胃癌是我国最常见的恶性肿瘤之一,尽管应用手术联合化疗、热疗、放疗等多种方法,但是很难控制胃癌进展.树突状细胞被认为是刺激静止性T淋巴细胞激活初级免疫反应最有潜力的抗原提呈细胞,在胃癌的免疫监视及免疫逃逸机制中起重要作用,与胃癌的发生、发展、愈后密切相关,树突状细胞在胃癌生物免疫治疗中成为研究热点.