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  5. In vitro and in vivo replication of a chemically synthesized consensus genome of hepatitis B virus g

In vitro and in vivo replication of a chemically synthesized consensus genome of hepatitis B virus g

来源 :2014年APASL专题会议暨第四届乙型病毒性肝炎专题会议 | 被引量 : 0次 | 上传用户：aiwuziji
【摘 要】
：
Background:Hepatitis B virus(HBV) genotypes vary in their geographical distribution and virological features.Previous investigations have shown that HBV genotype B is a predominant HBV genotype in Chi
【作 者】
：
Zhenhua Zhang Jianbo Xia Xu Li Mengji Lu 
【机 构】
：
Department of Infectious Diseases,the First Affiliated Hospital,Anhui Medical University
【出 处】
：
2014年APASL专题会议暨第四届乙型病毒性肝炎专题会议
【发表日期】
：
2014年4期
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Background:Hepatitis B virus(HBV) genotypes vary in their geographical distribution and virological features.Previous investigations have shown that HBV genotype B is a predominant HBV genotype in China.Studies on HBV concerning different isolates frequently meet the question about the HBV reference strain and its representativeness.Although HBV consensus sequences can be generated easily by sequence alignment,they may not exist in nature or could not usually be isolated from patient samples.Thus,the construction of a consensus HBV genome has been proposed.
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