Molecular Dynamics Simulation on Interaction between Focal Adhesion Kinase and Its Four Inhibitors

来源 :第七届国际分子模拟与信息技术应用学术会议 | 被引量 : 0次 | 上传用户:RubbishHP
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
Focal adhesion kinase (FAK) is a non-receptor protein tyrosine kinase, which plays important roles in a series of cell signaling pathway, such as cellmigration, proliferation, and survival.Whats more, it is also concered in cancer development, progression and tumor angiogenesis.
其他文献
For biosynthesis of bacillamide C by Bacillus atrophaeus C89 associated with South China sea sponge Dysidea avara, it is hypothesized that decarboxylation from L-tryptophan to tryptamin e could be per
会议
The interaction of copper compounds with DNA is significant in a variety of biological processes [1].A series of six molecular dynamics simulations were performed to investigate the interaction betwee
会议
The thermophilic intracellular protease (PH1704) from Pyrococcus horikoshii that functions as an oligomer (hexamer or higher forms) has proteolytic activity and remarkable stability.PH1704 is classifi
Background: Toll-like receptor 9 (TLR9) recognises unmethylated CpG DNA and activates a signalling cascade, leading to the production of inflammatory cytokines such as TNF-α, IL-1, IL-6 and IL-12 via
会议
WW domain proteins are usually regarded as simple models for understanding the folding mechanisrn of β-sheet.CC45 is an artificial protein that is capable of folding into the same structure as WW doma
The α1β2γ2 gamma-aminobutyric type A receptor (GABAAR) is one of the most widely expressed GABAAR sub-types in the mammalian brain.GABAARs belonging to the Cys-loop superfamily of ligand-gated ion cha
We performed molecular docking and molecular dynamics (MD) simulation method to investigate the interaction between ASK1 receptors and small molecules RITA.First, the molecular docking program was use
Antibody stability is very important for expression, activity, specificity and storage.The present knowledge of antibody structure has made it possible for a computer-aided molecule design to be used
Background: Leucine-rich repeats (LRR) within the extracellular domain of human TLR9 (hTLRg) mediate binding to CpG ODN.Resultts: LRR11 ofhTLR9 has high affinity for CpG ODN, whereas the mutants of fi
会议
c-MET is a receptor protein-tyrosine kinase whose activating ligand is hepatocyte growth factor/scatter factor (HGF/SF).Because of the critical roles of aberrant signaling in cancer, c-MET is an attra