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Objectives: To assess absolute weight change(AWC),≥ 7%weight gain(WG),and self-reported WG of antipsychotics in mania,bipolar depression,and bipolar maintenance.Methods: Studies were identified through PudMed search.AWC,≥ 7%WG,and self-reported WG were extracted from original publications.Difference(s)in AWC between an active treatment and placebo/comparator was based on original significance test or re-calculated with t-test.Differences in ≥ 7%WG,and/or self-reported WG were estimated with the number needed to treat to harm(NNH).