A seed expansion graph clustering method for protein complexes detection in protein interaction netw

来源 :第二届中国计算机学会生物信息学会议 | 被引量 : 0次 | 上传用户:vitalee
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  Most proteins perform their biological functions while interacting as complexes.The detection of protein complexes is an important task not only for understanding the relationship between functions and structures of biological network,but also for predicting the function of unknown proteins.In the paper,we present a new measure of a node to reflect its representability to a cluster in a protein interaction(PPI)network by integrating the topological information of its neighborhood,which reflects representability of the node in a larger local neighborhood using an iterative procedure.
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