Fe-based alloys of bcc phase are considered as the promising structural materials in fusion reactor.Large amounts of H impurities are produced concurrently along with irradiation damage in the structural materials under neutron irradiations.Ions irradiations have been carried out to study neutron irradiation damage effect in fusion materials,e.g.,Ne and H/He ions.As a continuation of our previous efforts on H/He behavior with vacancy in bcc Fe [1-3],to understand effects of Ne on H retention in Fe based alloys,in this work,we investigated the preference sites of Ne and interaction between Ne and H within bcc Fe host lattices using first-principles calculations.