膳食辣椒素激活TRPV1改善心肌线粒体功能减轻高盐介导的心肌肥厚

来源 :中国病理生理学会心血管专业委员会第十五届学术大会暨国际心脏研究会中国分会第十二届学术大会 | 被引量 : 0次 | 上传用户：gan402771387

【摘要】

：

目的:探讨长期高盐摄入对小鼠心脏结构与功能的影响,以及给予膳食因子辣椒素能否通过改善心肌线粒体功能而有效预防高盐引起的心脏损害.方法:出生6～8周的野生型和TRPV1敲除型雄性小鼠分别给予普食、高盐(8％)、高盐(8％)加辣椒素(0.01％)饮食干预24周,超声评价心脏结构和功能,高分辨率细胞呼吸测量仪检测心肌线粒体功能,小动物跑步机测量运动耐力,用Western blotting方法检测心肌线粒

【作者】

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郎红梅于浩李强路宗师熊诗强张和轩王非黎鹏赵宇杨涛黄小虎商黔惠刘道燕祝之明

【机构】

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第三军医大学全军高血压代谢病中心,重庆大坪医院高血压内分泌科,重庆市高血压研究所,重庆400042

【出处】

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中国病理生理学会心血管专业委员会第十五届学术大会暨国际心脏研究会中国分会第十二届学术大会

【发表日期】

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2014年3期

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膳食辣椒素激活TRPV1改善心肌线粒体功能减轻高盐介导的心肌肥厚

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