Peritoneal Dialysis for Autosomal Dominant Polycystic Kidney Disease: ARetrospective Study

来源 :浙江省生物医学工程学会肾脏病透析移植分会2015年学术年会 | 被引量 : 0次 | 上传用户:savage10000
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  Objectives: Describe the long-term clinical outcomes of patients with autosomal dominant polycystic kidney disease(ADPKD)on peritoneal dialysis(PD)therapy.Methods: We performed a retrospective matched-cohort analysis comparing the clinical outcomes of 30 ADPKD patients to 60 nondiabetic patients with bilateral small kidneys between 1 July 2007 and 31 July 2014.The patient groups were matched by age,gender and time of PD initiation.Results: There were no significant differences in demographic and biochemical parameters,comorbid conditions,residual glomerular filtration rate and charlson comorbidity score at the beginning of PD.The median renal volume was 1315ml for the ADPKD group and 212 ml for the control group.Patients with ADPKD had similar 5 year patient survival(65.0%versus 86.8%,P =0.57)and technique survival(46.3%versus 59.1%,P =0.85)compared with non-ADPKD patients.There was also no significant difference in peritonitis-free survival between the ADPKD and control group(P =0.25),the rates of peritonitis were also similar(0.19 versus 0.21 episodes per patient-year,P =0.37).No differences were observed in the incidence of PD-related complications such as hernia and dialysate leak.Conclusions: Our result shows that the patient and technique survival of ADPKD patients on PD therapy are similar to the nondiabetic patients with bilateral small kidney.ADPKD is not a contraindication for peritoneal dialysis.
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