The design of magnetic nanoparticle-based targeting systems has gained considerable attention in the field of nanotechnology due to the requirement of more potent and selective tumor-targeted diagnostic and therapeutic agents [1,2].These so-called "specific targeting nanoparticles" are comprised of magnetic cores that enable tracking through magnetic resonance imaging(MRI)and are surface-modified with targeting ligands that have high affinity to cancer biomarkers.A number of ultrafine superparamagnetic iron oxides(USPIOs)are either in experimental stages or early clinical trials,and several formulations have been approved for clinical use[3].