【摘 要】
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L-carnitine, a naturally occurring quaternary ammonium compound, was discovered in muscle extraacts in the beginning of twentieth century.In humans, 75 % of
【机 构】
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Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University Kingdom of Saud
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L-carnitine, a naturally occurring quaternary ammonium compound, was discovered in muscle extraacts in the beginning of twentieth century.In humans, 75 % of the total body carnitine originates from dietary sources and the remaining 25 % from endogenous synthesis.It is well documented that cachectic cancer patients are especially at risk for carnitine insufficiency due to decreased oral intake, inhibition of endogenous synthesis and increased renal losses.Also, altered serum and urine camitine levels have been reported in cancer patients with various forms of malignant diseases including testicular, ovarian and gastrointestinal carcinoma.
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