【摘 要】
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Object:Interferon-α(IFN-α)treatment induce antiviral responses by induction of interferon stimulated genes,which can directly inhibit viral replication,as well as influence innate and adaptive immune
【机 构】
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Department of Infectious Diseases and Center of liver Diseases,Tangdu Hospital,the Fourth Military M
【出 处】
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中华医学会第十七次全国病毒性肝炎及肝病学术会议暨2015年中华医学会感染病学分会年会、中华医学会肝病学分会年会
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Object:Interferon-α(IFN-α)treatment induce antiviral responses by induction of interferon stimulated genes,which can directly inhibit viral replication,as well as influence innate and adaptive immune response through expansion of activated CD8+T cells,NK cells,maturation of dendritic cells and augmentation of B cell responses.However,the IFN-α effect on variation of nave CD8+T cell was rarely studied.Meanwhile,CD100 is an important regulator expressed on various immune cells.It is proved that IFN-α induced CD100 expression on B cells is associated with control of hepatitis C virus infection.To further observe CD100 functions on CD8+T cells during HCV infection and IFN-α therapy,CD8+T and its subsets have been studied in vivo and in vitro.
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