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  5. Pretreatment with poly(I:C) enhances the therapeutic activity of mesenchymal stromal cells in animal

Pretreatment with poly(I:C) enhances the therapeutic activity of mesenchymal stromal cells in animal

来源 :The 14th Congress of Gastroenterology China(第十四届全国消化系病学术会议) | 被引量 : 0次 | 上传用户：yuanjian2009
【摘 要】
：
Background Mesenchymal stromal cells (MSCs) are currently under investigation for the treatment of inflammatory disorders,including Crohns disease.MSCs are pluripotent cells with immunosuppressive pro
【作 者】
：
Y.Qiu R.Mao K.Chao M.Y.Li B.L.Chen Y.He Z.R.Zeng M.H.Chen 
【机 构】
：
Department of Gastroenterology, First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Peop
【出 处】
：
The 14th Congress of Gastroenterology China(第十四届全国消化系病学术会议)
【发表日期】
：
2014年5期
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Background Mesenchymal stromal cells (MSCs) are currently under investigation for the treatment of inflammatory disorders,including Crohns disease.MSCs are pluripotent cells with immunosuppressive properties.Growing evidence indicates that resting MSCs do not have significant immunomodulatory activity, but that TLR3 (poly(I:C)) priming entails MSCs immunosuppressive activity.Thus, we assessed the effects of poly(I:C)-primed MSCs on their immunosuppressive properties in vitro and in vivo.
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