Objective The purpose of this study was to evaluate the out-comes of computed tomography (CT) guidance using percu-taneous catheter with low-dose drainage local chemotherapy (modified PCD) and antituberculous therapy (ATT) for the treatment of spinal tuberculosis in children.Methods Twenty-seven children suffering from spinal tuber-culosis were treated with modified PCD and ATT in our insti-tute from 2002 to 2012.We describe our treatment,which involves CT-guided percutaneous puncture and local chemo-therapy (continuous low-dose (20 mL) irrigation).The pa-tients were evaluated based on the Frankel scoring system,the kyphotic Cobb angle,and the erythrocyte sedimentation rate (ESR).Results All patients were followed up for an average of 31.00 ± 13.94 months.No sinus formation was detected.All patients responded well to this treatment.The ESR values were de-creased to normal at last follow-up.The neurological func-tions show significant improvement after operation.Preoper-atively,the kyphotic angle was 22.89±7.06°,and it was mea-sured as 21.19±8.73° at the last visit.Conclusions Our results showed that percutaneous intubation and low-dose irrigation under CT guidance (modified percu-taneous catheter drainage (MPCD)) and ATT are easy,safe,efficient,and less invasive methods for the treatment of spinal tuberculosis in children.