Hsp90 is a molecular chaperone responsible for facilitating maturation of client proteins include oncogenic tyrosine kinase,transcription cofactors and cell-cycle proteins,and has long been recognized
Microglia,the resident phagocytes of the CNS,plays an important role in the active immune defense and the progression of neuroinflammation.It is reported that inhibition of microglial activation contr
Alzheimers Disease (AD) is the most common form of dementia.The multi-target-directed ligands(MTDLs) designed for this fatal neurodegenerative disorder exhibit promising therapeutic potential.