【摘 要】
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The aim is to study the effects and possible mechanism of Laminaria Japonica polysaccharide (LJPS) on leptin level in serum and leptin receptor expression in hypothalamus of hyperlipemia mice.Eighty a
【机 构】
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Department of Cardiology, Affiliated Hospital of Qingdao University, Qingdao 266003, China
【出 处】
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第二届中国针灸学会针灸康复专业委员会第二次学术会议、第三届山东中西医结合学会康复医学专业委员会第一次学术会议、第一届山东
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The aim is to study the effects and possible mechanism of Laminaria Japonica polysaccharide (LJPS) on leptin level in serum and leptin receptor expression in hypothalamus of hyperlipemia mice.Eighty adult healthy male mice were randomly divided into control group, model group, and treated group.The hyperlipemia models of mice were established by feeding fat-rich forages for four weeks and treated by LJPS orally for two weeks.Blood lipid levels in serum were determined by automatic biochemical analyzer and the leptin level in serum was determined by enzyme linked immunosorbent assay (ELISA).The immunohistochemistry and Western blot were used to detect the expression of leptin receptor (OBR) protein and RT-PCR to detect the expression of OBR mRNA in hypothalamus tissue.The results indicated that the serum levels of lipids and leptin decreased significantly than those in model group (P<0.05) after treated with LJPS.In hypothalamus tissue, the expression level of OBR mRNA and its protein were significantly higher than those in model group (P<0.05).It is concluded that LJPS might reduce blood lipid levels in hyperlipemia mice by promoting the expressions of OBR and reducing leptin resistance.
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