【摘 要】
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Furans are a ubiquitous structural motif in numerous naturally occurring products,[1] synthetic pharmaceuticals,[2] agrochemicals,and also useful building blocks in organic synthesis.[3] Herein,we pro
【机 构】
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School of Chemistry and Chemical Engineering,South China University of Technology,Guangzhou,510640
【出 处】
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中国化学会全国第十二届有机合成化学学术研讨会
论文部分内容阅读
Furans are a ubiquitous structural motif in numerous naturally occurring products,[1] synthetic pharmaceuticals,[2] agrochemicals,and also useful building blocks in organic synthesis.[3] Herein,we propose a copper-mediated [2+3] oxidative cyclization to synthesize 2,3,5-trisubstituted furans from N-tosylhydrazones and β-ketoesters.This process is thought to construct C-C and C-O bonds through the oxidative cyclization of vinyl copper species and β-ketoesters free radical intermediates.[4] To the best of our knowledge,this is the first attempt utilizing N-tosylhydrazones compounds as building blocks to synthesize furans.The studies provide important complementary approaches for synthesizing substituted furans.
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