【摘 要】
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Indlizines and thire derivatives,which exhibit intriguing molecular structures featured by an N-bridgehead bicyclic ring system fused with both a π-excessive pyrrole and a n-deficient pyridine, have b
【机 构】
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广西师范大学化学与药学学院 广西541004
【出 处】
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中国化学会全国第十一届有机合成化学学术研讨会
论文部分内容阅读
Indlizines and thire derivatives,which exhibit intriguing molecular structures featured by an N-bridgehead bicyclic ring system fused with both a π-excessive pyrrole and a n-deficient pyridine, have been employed as an important basic building block in a wide range of natural products and pharmaceuticals.Many indolizines have shown important biological activities,such as antibacterial, antiviral, anti-HIV, anti-inflammatory, 5-HT3 receptor antagonist, muscular relaxant, as well as antioxidant.A new silver-mediated highly selective C-H functionalization of 2-alkylazaarenes with internal and terminal alkynes for the creation of substituted indolizines in one-pot has been demonstrated.This process firstly represents a simple,efficient and atom-economic way to construct polysubstituted indolizines in good yields from internal and terminal alkynes through C-H fimctionalization of 2-alkylazaarenes.
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