【摘 要】
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SP110, a leukocyte-specific nuclear body component, has previously been shown to be a genetic determinant of host resistance to the intracellular pathogen infection.Though this gene has been reported
【机 构】
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College of Veterinary Medicine, Northwest A&F University, Key Laboratory of Animal Reproductive Endo
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SP110, a leukocyte-specific nuclear body component, has previously been shown to be a genetic determinant of host resistance to the intracellular pathogen infection.Though this gene has been reported in mouse and human, its relevant biological information in large animals still needed to be confirmed.Here we report the novel discovery and identification of three horse SP110 transcript variants.After open reading frame (ORF) and conserved domain (CD) analysis, the transcript variant 1 (Tv1) was predicted to have four domains (Sp100, SAND, PHD and Bromo domain), Tv2 and Tv3 were to have the same Sp100 and SAND domains as well as the classic mouse SP110 (Ipr1).
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