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Introduction: Intracranial fusiform aneurysm constitutes a relatively uncommon subgroup of aneurysms.Few reports concentrate on creation of fusiform aneurysm in carotid artery in large animals.In the study,we compare the technical feasibility and angiographic features of a canine model of carotid fusiform aneurysm created by surgical venous-graft with the model induced by porcine elastase with or without balloon-assistance.Materials and Methods: Fifteen beagle canines(weighted3Kg-4Kg)included in the study and randomly divided into 3 groups,each with 5 canines: Group 1,porcine pancreatic elastase induced model; Group 2,porcine pancreatic elastase induced model with a balloon assistance; and Group 3,surgically venous-grafted model.The surgically successful rate and the successful rate of aneurysm formation were compared between the 3 groups.An initial digital subtract angiography(DSA)was performed immediately after the creation of model and follow-up angiography was performed at 2 weeks and 4 weeks.Results: One dog was excluded from Group 3.The technically successful rate for group1,2 and 3 is 100%,100%and 80%,respectively.At immediate angiography,the diameter of dilated carotid arteries increased significantly compared to control arteries in group1(4.84 ± 0.25 vs.3.20 ±0.10mm),2(4.71 ± 0.21vs.3.39 ±0.12mm)and 3(8.18 ± 0.65 vs.3.99 ±0.05 mm).Arterial dissection was observed in 2 of 5 animals in group1.At follow-up angiography,3 models keep medium arterial enlargement and 2 models slight enlargement in group1; signs of thrombosis appeared in 2 models at 2 weeks and carotid arterial occlude in all models at 4 weeks in group2; no apparent change in size and morphology was found in group3.Conclusions: The canine model of fusiform aneurysm of the carotid artery created by surgical venous-graft yields similar success rates compared with other models,but the aneurysm is more predictable and stable by angiography.The model induced by porcine elastase with balloon-assistance also yields a high rate of aneurysm formation.However,the balloon might increase the risk of thrombosis; this did not occur in our model.