Developing nanomaterials as carriers for drug delivery have become a hot research field.In this study,a peptide-based nanofiber hydrogel(we call it NMe,which contains four amino acids backbone(glycine-phenylalanine-phenylalanine-tyrosine),in which N-terminal and C-terminal is modified by naphthalene acetic acid and methylamino group respectively)is used as the carrier for the delivery of theraputic nuclear acid vaccine.In vitro result shows that NMe can compress the incompact wirelike DNA into the compact sphere DNA,resulting in a significantly increased internalization of DNA by cells.