In mammals, active DNA demethylation involves oxidation of 5-methylcytosine (5mC) into 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC) by Tet dioxygenases
Primed enhancers are marked by histone H3K4 mono-methylation (H3K4me1), and the conversion to active enhancers involves acetylation of histone H3K27 (H3K27Ac).
Phosphorylated histone H2AX, also termed γH2AX, mediates the chromatin response to DNA double strand break (DSBs) in mammalian cells and assists DSB repair.
Vigilin, a multi-KH-domain protein, participates in heterochromatin formation.CCCTC-binding factor (CTCF) has been implicated in numerous aspects of chromosome
The Mediator complex orchestrates multiple transcription factors with the Pol Ⅱ apparatus for precise transcriptional control.However, its interplay with t
Glucose metabolic reprogramming is a hallmark of cancer.Cancer cells rapidly adjust their energy source from oxidative phosphorylation to glycolytic metabolism
Objective—Endothelial cells (ECs) form blood vessels through angiogenesis, and participate in maintaining tissue homeostasis by cell fate change through endoth