H3K27me3 mark constrains nucleosome dynamics in nonproliferating cells

来源 :第七届全国生物信息学与系统生物学学术大会 | 被引量 : 0次 | 上传用户：MHSLOVE

【摘要】

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【作者】

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彭勇艾珊珊李晨余先红李玉梅李鑫李程李川昀何爱彬

【机构】

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分子医学研究所,北京大学,北京100871;前沿交叉学科研究院,北京大学,北京100871;北大-清华生命科学联合中心,北京大学,北京100871

【出处】

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第七届全国生物信息学与系统生物学学术大会

【发表日期】

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2016年8期

【关键词】

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Nucleosome Turnover H3K27me3 PRC2 Heart diseases

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　　Nucleosome dynamics,facilitating histone exchange and increasing nucleosomal DNA accessibility,is an underexplored feature of chromatin-based transcriptional regulation in addition to histone marks,such as H3K27me3,a repressive mark tightly coupled with transcriptional repression.However,it still remains elusive how nucleosome dynamics cross talks with various histone marks.We hypothesized that H3K27me3 regulate nucleosome dynamics to execute silencing.

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H3K27me3 mark constrains nucleosome dynamics in nonproliferating cells

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