Inhibition of phosphodiesterase 2 reverses NADPH oxidase mediated depression-like behaviors

来源 :中国药理学会第十三次全国学术大会 | 被引量 : 0次 | 上传用户:sksliuxin6
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
  Depression is a recurring and potentidly lifethreatening disorderthat is major cause of morbidity and mortality. Stressful eventscan precipitate factors in the onset of major depressionand stress paradigms have long been used to modeldepressive status.
其他文献
Autophagy is a highly evolutionarily conserved pathway that depends on lysosome to degrade misfolded proteins and damaged organelles.Besides canonical autophagy, studies have shown some chemicals coul
Aim βguanadinopropionic acid (βGPA), a creatine analog has been demonstrated to lead to the chronic activation of AMPK with increasing mitochondrial biogenesis.However, little is known about the effec
A large body of epidemiological and clinical evidences indicated that smoking has a protective effect in patients with ulcerative colitis (UC).Although it is generally believed that nicotine accounts
Aim To investigate the role of CKLF1 in SHSYSY cell migration and its molecular regulatory mechanism.Methods SHSY5Y cells were stimulated with CKLF1 for 0.5, 2, 8 and 24 h, respectively.The migration
Hypoxia preconditioning (HPC) is associated with many complicated pathophysiological and biochemical processes that integrated and regulated via molecular levels.HPC could protect cells, tissues, orga
Purpose: Fibronectin type Ⅲ domaincontaining protein 5 (FNDC5), also known as irisin, is a myokine secreted from muscle in response to exercise and improves obesity and glucose homeostasis.However, th
Insulin sensitizing medicines are currently limited, and identification of new drug candidate is a challenge.Protein tyrosine phosphatase 1B (PTP1 B) negatively regulates insulin signaling pathway, an
In silico prediction of drugtarget interactions from heterogeneous biological data can advance our systemlevel search for drug molecules and therapeutic targets, which efforts have not yet reached ful
会议
Exosomes ( EXs, 30~120 nm) and microvesicles ( MVs, 100~ 1000 nm) are two types of extracellularmicroparticles. Their contents (miRs and proteins) vary depending on cell origin and status. Mounting ev
会议
PDE is a superfamily of enzymes that break down the important second messengers cyclic AMP ( cAMP)and cyclic GMP ( cGMP) . There are 11 PDE families ( PDEl11); among them , PDE4 is the most important
会议