【摘 要】
：
Artemisinin derivatives have shown inhibitory activity against tumor cells in various ways,especially revealed collateral sensitivities in some multidrug-resistant cancer cell lines.Dihydroartemisinin
【机 构】
：
Key Laboratory of Structure-Based Drug Design and Discovery(Shenyang Pharmaceutical University),Mini
【出 处】
：
第九届IUPAC化学生物学国际研讨会暨第八届世界华人药物化学研讨会
论文部分内容阅读
Artemisinin derivatives have shown inhibitory activity against tumor cells in various ways,especially revealed collateral sensitivities in some multidrug-resistant cancer cell lines.Dihydroartemisinin was taken as the leading compounds,and a series of artemisinin derivatives were designed and synthesized which had the nitrogen-containing substituents at the position of C-1O of dihydroartemisinin linked with phenacetyl group.All of these artemisinin derivatives possessed evidently improved effects than dihydroartemisinin against MCF-7 cells growth,GI50=0.500μM~8.00μM.Among them,compounds ZH04,ZH06 and ZH09,which GI50 are 0.549μM、0.516μM and 0.790μM respectively,showed the strongest activity against MCF-7 cells growth.Some of these artemisinin derivatives showed stronger activity against MCF-7/Adr cells than against MCF-7 cells.At the same time,they possessed improved effects than dihydroartemisinin and adriamycin against MCF-7/Adr cells growth.
其他文献
The ideal synthesis is pursued actively by organic chemists since it encompasses the ideas of atom,step,redox-economy,as well as economies of time,labor,resource management,and waste generation.As suc
Rubiginones are a family of the natural products that have been isolated from the fermentation broth of Streptomyces griseorubiginosus.Rubiginone A2 1 was claimed to be useful in the treatment of AIDS
Over the past decades,considerable attention had been focused on the development of peripherally acting selective κ-opioid receptor agonists devoid of many side effects associated with μ-agonists and
Autophagy,an evolutionarily conserved lysosomal degradation pathway,has been implicated in a wide variety of cellular processes,and the underlying mechanisms have been extensively studied.Yet,the fusi
Novel histone demethylase LSD1 inhibitors were found to specifically inhibit the proliferation of pluripotent cancer cells including teratocarcinoma,embryonic carcinoma,and seminoma or embryonic stem
Danshensu(DSS),the water-soluble active component of Danshen,is the main constituent responsible for many of Danshens biologic activities including cardioprotective properties in various experimental
Flavonoids and its derivatives are common components found intraditional Chinese medicine and food.Numerous studies indicated that,besides the cancer prevention function,flavonoid-containing agents mi