In this talkfollowings are presented and discussed: 1, who was the person who discovered this disease 2.How has the research committee of the ministry of health and welfare of Japan RCMHWJ contributed to clarify the epidemiology, etiology, pathophysiology and treatments.3.How has been the situation in other countries than Japan, especially Euroamerican countries and Asian countries, about these topics.4.How havedeveloped varioustreatments and who didrevascularization procedures for the first.5.Update of the disease.