【摘 要】
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OBJECTIVE Sigma-1 receptors are involved in the pathophysiological process of several neuropsychiatric diseases such as epilepsy,depression.Allosteric modul
【机 构】
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JiangsuKeylaboratoryforTranslationalResearchforNeuropsychiatricdiseases,TheCollaborativeInnovationCe
【出 处】
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第十七届全国神经精神药理学学术会议
论文部分内容阅读
OBJECTIVE Sigma-1 receptors are involved in the pathophysiological process of several neuropsychiatric diseases such as epilepsy,depression.Allosteric modulation represents an important mechanism for receptor functional regulation.In the present study,we examined antidepressant activity of the latest identified novel and selective allosteric modulator of sigma-1 receptor SOMCL-668(3-methyl-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-ol).
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