论文部分内容阅读
Metal ions play various important biological functions in proteins including structural maintenance,molecular recognition and catalysis.
Coevolution-based prediction of metal binding sites in proteomes by machine learning
【摘 要】
：
Metal ions play various important biological functions in proteins including structural maintenance,molecular recognition and catalysis.
【机 构】
：
Synthetic and Functional Biomolecules Center,Beijing National Laboratory for Molecular Sciences,Key
【出 处】
：
第十一届全国化学生物学学术会议
【发表日期】
：
2019年3期
其他文献
Nanoparticle-Regulated Semiartificial Magnetotactic Bacteria with Tunable Magnetic Moment and Magnet
Micro-/nanomotors are widely used in micro-/nanoprocessing,cargo transportation,and other microscale tasks because of their ability to move independently.
以超小Fe3O4 纳米粒子为T1 加权成像造影剂，具有类沸石咪唑框架材料ZIF-8 为载体，构建了具有pH 和谷胱甘肽响应的T2-T1 反转的磁共振造影剂Fe3O4-ZIF-8.
DNAzymes 是有效的基因治疗药物,而低效的细胞内递送能力和不足的辅助因子阻碍了它们的实际生物应用。[1,2]金属有机框架化合物已成为有前途的药物递送载体,然而很少有报道深入研究它们的组成成分。
Self-Assembled and Size-controllable Oligonucleotides Nanospheres for Effective Antisense Gene Deliv
Oligonucleotide-based gene therapy holds immense promise for the treatment of a variety of diseases,including cancer,inherited diseases,and viral infections.
一氧化碳(CO)和血红蛋白有很强的结合能力，会降低血红蛋白对氧气的运输能力，因此CO 又被称为沉默的杀手。然而，几十年的研究表明，内源性CO 是一种普遍存在的第二信使，参与广泛的生理和病理反应，如炎症、增殖和凋亡。
A Tailored Multifunctional Anticancer Nanodelivery System for Ruthenium-Based Photosensitizers:Tumor
Ruthenium complexes are promising photosensitizers(PSs),but their clinical applications have many limitations.
纳米酶兼具酶和纳米材料的“双重身份”，区别于天然酶和传统模拟酶，纳米酶的高稳定性和催化活性使它在生物医学、生物传感器、免疫分析和癌症治疗等领域的研究受到广泛的关注。
Precisely-assembled nanoparticles against cisplatin-resistance via cancer-specific targeting of mito
Cisplatin resistance in tumor cells is known mainly due to the reduced accumulation of platinum ions by efflux,detoxification by intracellular GSH,and nucleotide excision repair machinery mediated nuc
Expanding the Genetic Code for Suppression of Premature Termination Codons to Alleviate Human Nonsen
Nonsense mutations with premature termination codons(PTCs)account for approximately 11%of reported monogenic diseases.