Discovery of novel Bcr-Abl inhibitors with diacylated piperazine as flexible linker

来源 :2015年全国药物化学学术会议暨第五届中英药物化学学术会议 | 被引量 : 0次 | 上传用户：yatai1980

【摘要】

：

Forty-two compounds(series 8,9 and 10)incorporated with diacylated piperazine have been synthesized and evaluated as novel Bcr-Abl inhibitors based on six-atom linker.

【作者】

：

Xiaoyan PAN Jie ZHANG

【机构】

：

School of Pharmacy,Xi'an Jiaotong University,No.76,Yanta West Road,Xi'an,710061

【出处】

：

2015年全国药物化学学术会议暨第五届中英药物化学学术会议

【发表日期】

：

2015年3期

【关键词】

：

Bcr-Abl inhibitors ATP binding site Imatinib bioactivity docking CoMFA

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　　Forty-two compounds(series 8,9 and 10)incorporated with diacylated piperazine have been synthesized and evaluated as novel Bcr-Abl inhibitors based on six-atom linker.

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