【摘 要】
:
Epidermal growth factor (EGF) receptor is a tyrosine kinase which regulates cell growth and differentiation and is implicated in many human cancers.In vivo site-specific labeling of fluorescent or fun
【机 构】
:
Department of Chemical Biology, College of Chemistry and Molecular Engineering, Peking University, B
论文部分内容阅读
Epidermal growth factor (EGF) receptor is a tyrosine kinase which regulates cell growth and differentiation and is implicated in many human cancers.In vivo site-specific labeling of fluorescent or functional probes on EGFR contributes to protein trafficking and dynamics study in physiological conditions.
其他文献
Oxime and oxime ethers have attracted much interest due to their chemical properties and biological activity.Steroidal oximes and their derivatives are known to exhibit anti-inflammatory, anticancer a
镧系金属在人工合成核酸酶中可以很好地催化RNA水解,但其毒性较大,为了使其能应用于生物体,可以把镧系离子包裹在配体里形成稳定的穴状配合物.我们合成了两个含侧臂的Cyclen衍生物(THP和DOTAM)并得到了其与铽的配合物,研究了配合物在不同pH值下催化RNA和DNA模拟物的水解反应.
Studies have shown that two novel ruthenium(Ⅱ) Polypyridyl complexes hydrophobic ancillary ligands have relatively strong anticancer activity, cell uptake of drugs have a crucial impact on the pharmac
P450单加氧酶参与着生物体生命活动的多种进程,在人体内主要存在于肝脏,参与药物、酒精等外源性物质的代谢,同时参与甾体、脂肪酸、前列腺素等内源性生理化合物的代谢合成[1].CYP119酶是P450酶系统中的一种源于硫矿硫化叶菌.目前已有CYPll9催化苯乙烯,月桂酸等的羟基化反应,但是其催化效率及立体选择性相对较低[1,2].
Due to the excellent property of complementary base pairing, double-strand nucleic acid is widely applied in the field of nanomaterials building.At the same time, nucleic acid nanoparticle, is also a
单加氧酶CYP119来自嗜酸嗜热古菌Sulfolobus solfataricus,其基因序列和晶体结构已被确认[1,2].但到目前为止该酶的内源性底物还未被发现.目前已证实其具有催化苯乙烯环氧化反应及月桂酸羟基化反应等作用.Ortiz de Montellano小组报道了野生型CYP119在过氧化氢存在下催化非天然底物苯乙烯发生环氧化反应,突变体T214V能明显改善与苯乙烯的结合能力,过氧化氢途
楝科植物是天然界中柠檬苦素类成分主要来源,到目前为止,已从楝科植物中发现超过1160个各种类型的柠檬苦素类化合物,它们具有杀虫、昆虫拒食、抗微生物、抗病毒、抗肿瘤、抗炎等广泛生物活性.铁椤(Amoora tsangii (Merr.)X.M)为楝科崖摩属植物,是海南特有植物,在当地常用其树皮煎汁来祛虱.
手性药物在体内的药理活性、代谢过程及毒性存在着显著差异[1].因此,手性表征及识别在生命过程中极其重要.本文利用室温磷光光谱法以及时间分辨磷光光谱法实现了对氧氟沙星对映体的手性识别,同时,借助分子模拟等方法[2]进一步对分子手性识别机理进行了探讨.
Multi-targeting anticancer drug that a molecule termed combi-molecule (C-molecule) with binary epidermal growth factor receptor (EGFR) targeting/DNA-damaging properties can overcome the limitations of
Heme is a prosthetic group for many essential proteins involved in diverse biological processes, but excess heme can be highly toxic to cells.There is currently a lack of direct and quantitative metho