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目的探讨空腹血糖(FPG)、糖化血红蛋白(HbA1c)与2型糖尿病(DM)肾功能的关系。方法选269例2型DM患者分别以FPG、HbA1c进行分组,分析比较FPG、HbA1c与其血清肾功能即尿素(Urea)、肌酐(Cr)、尿酸(UA)关系。按FPG(mmol/L)分组:6.111.1(C组);按HbA1c(%)分组:HbA1c≤6.5(A1组),6.57.6(C1组)。另选健康体检者60例为正常对照组。结果与对照组相比,B、C两患者组Urea和Cr差异均有统计学意义(P<0.01),而A组差异无统计学意义(P>0.05);与A组相比,C组的Urea和Cr差异有统计学意义(P<0.01)。与A1组相比,B1、C1两组的Urea和Cr差异均有统计学意义(P<0.01);与B1组比,C1组差异无统计学意义(P>0.05)。UA差异均无统计学意义(P>0.05)。Urea和Cr与FPG均有显著相关(r=0.302,P<0.01;r=0.309,P<0.01);Urea和Cr与HbA1c也均有显著相关(r=0.236,P<0.01;r=0.181,P<0.01);UA与FPG、HbA1c均无显著相关(r=-0.062,P>0.05;r=-0.044,P>0.05)。结论 DM患者Urea和Cr随着FPG和HbA1c升高有不同程度的升高。高FPG和高HbA1c是DM肾功能损伤的危险因素之一,进行FPG和HbA1c联合检测有助于筛查和预防糖尿病肾病。
Objective To investigate the relationship between fasting blood glucose (FPG), glycosylated hemoglobin (HbA1c) and renal function in type 2 diabetes mellitus (DM). Methods 269 patients with type 2 diabetes mellitus (DM) were divided into two groups according to FPG and HbA1c. The relationship between FPG and HbA1c and their serum renal function, such as Urea, creatinine (Cr) and uric acid (UA) were analyzed. According to FPG (mmol / L) group: 6.1 11.1 (group C); HbA1c (%) group: HbA1c≤6.5 ), 6.5 7.6 (group C1). Another 60 healthy subjects were normal control group. Results Compared with the control group, the differences of Urea and Cr between the two groups were statistically significant (P <0.01), while there was no significant difference between the two groups (P> 0.05) The difference between Urea and Cr was statistically significant (P <0.01). Compared with group A1, the difference between Urea and Cr in B1 and C1 groups was statistically significant (P <0.01). Compared with B1 group, there was no significant difference in C1 group (P> 0.05). UA difference was not statistically significant (P> 0.05). There were significant correlations between Urea, Cr and HbA1c (r = 0.302, P <0.01; r = 0.309, P <0.01) P <0.01). There was no significant correlation between UA and FPG and HbA1c (r = -0.062, P> 0.05; r = -0.044, P> 0.05). Conclusion Urea and Cr in DM patients increased with different degrees of FPG and HbA1c. High FPG and high HbA1c are one of the risk factors of renal damage in diabetic nephropathy. Combined detection of FPG and HbA1c may be helpful in the screening and prevention of diabetic nephropathy.