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5. ThermoMatch: genome-wide oligonucleotide binding sites prediction based on thermodynamics

ThermoMatch: genome-wide oligonucleotide binding sites prediction based on thermodynamics

来源 :第六届全国生物信息学与系统生物学学术大会暨国际生物信息学前沿研讨会 | 被引量 : 0次 | 上传用户：zimomo

【摘 要】

：

Determination of oligonucleotide binding sites is crucial for nucleotide hybridization based molecular biological technology, such as PCR.Although sequence similarity method such as BLAST was adopted

【作 者】

：

刘哲言 卢一鸣 闵波 单光宇 屈武斌 张成岗 

【机 构】

：

北京放射与辐射医学研究所,蛋白质组学国家重点实验室,军事医学科学院,北京,100850;生命科学学院,安徽医科大学,合肥,230032

【出 处】

：

第六届全国生物信息学与系统生物学学术大会暨国际生物信息学前沿研讨会

【发表日期】

：

2014年4期

【关键词】

：

Thermodynamics ThermoMatch BLAST PCR 

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　　Determination of oligonucleotide binding sites is crucial for nucleotide hybridization based molecular biological technology, such as PCR.Although sequence similarity method such as BLAST was adopted by most software, it doesnt actually reflect the real hybrid states between oligonucleotide and its template sequence.

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