【摘 要】
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The aberrant proteolytic processing of amyloid precursor protein (APP) by b-secretase (BACE 1) and g-secretase is important for the generation of beta-amyloid protein in the Alzheimers disease (AD) br
【机 构】
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Department of Neurobiology and State Key Laboratory of Medical Neurobiology, Shanghai Medical Colleg
【出 处】
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中国神经科学学会第四次会员代表大会暨第七届全国学术会议(The 7th Biennial Meeting and the
论文部分内容阅读
The aberrant proteolytic processing of amyloid precursor protein (APP) by b-secretase (BACE 1) and g-secretase is important for the generation of beta-amyloid protein in the Alzheimers disease (AD) brains.Aβ is the major component of senile plaque and may be toxic to brain cells.To test weather BACE1 expression and beta-amyloid protein production can be induced by transient brain ischemia in a continuous way,and the toxicity of Aβ to brain cells.We use Middle Cerebral Artery Occlusion (MCAO) model,Animals were euthanized at 1d,3d,7d and 14d post-ischemia.Western blot analysis investigated that BACE-1 protein began to elevate at 1day and persisted up to 14days after ischemia compared to normal (P < 0.05).The alterations of BACE 1 protein levels were accompanied by corresponding increases of Aβx-42 peptides,which demonstrated by immunohistochemistry.
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