白蛋白与有机磷加合物位点识别及结构性质研究

来源 :中国化学会第14 届全国计算(机)化学学术会议暨分子模拟国际论坛 | 被引量 : 0次 | 上传用户：kongfuhei

【摘要】

：

有机磷化合物与人或动物体内蛋白质作用形成加合物,是检测和推断其是否中毒的重要依据。本文通过高分辨的质谱检测方法,研究了沙林等7种有机磷化合物对人、牛、大鼠、兔等种属的白蛋白体外染毒的加合物及其位点,得出14个白蛋白与有机磷加合物位点,14个作用位点是6个酪氨酸、7个赖氨酸、1个丝氨酸。

【作者】

：

丁俊杰孙凤娟丁晓琴王红梅

【机构】

：

北京药物化学研究所,北京,102205

【出处】

：

中国化学会第14 届全国计算(机)化学学术会议暨分子模拟国际论坛

【发表日期】

：

2017年10期

【关键词】

：

白蛋白有机磷加合物位点分子模拟

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白蛋白与有机磷加合物位点识别及结构性质研究

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