【摘 要】
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Transient receptor potential melastatin 7 (TRPM7) channels are widely expressed in the nervous system; however,their function and regulation are largely unk
【机 构】
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Department of Neurobiology, Tongji Medical College, Huazhong Science and Technology University, Wuha
【出 处】
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中国神经科学学会第四次会员代表大会暨第七届全国学术会议(The 7th Biennial Meeting and the
论文部分内容阅读
Transient receptor potential melastatin 7 (TRPM7) channels are widely expressed in the nervous system; however,their function and regulation are largely unknown.This study aimed to explore whether the current mediated by TRPM7-1ike channels in rat CA1 hippocampal neurons could be modulated by nerve growth factor (NGF).Using whole-cell patch clamp techniques,we identified an outward-rectifying TRPM7-1ike current in hippocampal neurons freshly isolated from postnatal (10-day-old) rats.The outward component of this current was reversibly reduced by NGF in dose-and time-dependent manners,and this effect was substantially blocked by K252a,an inhibitor of TrkA.In addition,NGF-induced reduction of the TRPM7-1ike current was abolished by U73122,a phopholipase C inhibitor.In light of the abundance of NGF in hippocampus that express both TrkA and TRPM7,these results suggest that the function of TRPM7-1ike channels in hippocampal neurons may be regulated by NGF.
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