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Background, Motivation and Objective The cardiovascular blood flow is very complex as it propagates in all three dimensions, where short-lived vortices can arise and vanish within 100-200 ms. Thus, to provide the true dynamics of the blood flow, 3-D vector flow imaging at a high frame rate is a necessity. However, current methods for velocity estimations are restricted to 1-D or 2- D methods. To solve these problems, a method for estimating 3-D vector flow in vivo at 2100 fps is presented.